Molecular stool screening for colorectal cancer
نویسندگان
چکیده
منابع مشابه
Stool DNA and colorectal-cancer screening.
Colorectal-cancer screening in the United States is a success story. The American Cancer Society recently reported that rates of death from colorectal cancer are down by 46% from their peak.1 There is good evidence that screening efforts have played an important role in the trend.2 However, work remains to be done, since approximately one third of Americans report not being current with screeni...
متن کاملA comparison of three stool tests for colorectal cancer screening.
The annual guaiac or immunochemical fecal occult blood test (FOBT) is one of the five colorectal cancer (CRC) screening regimens recommended by the American Cancer Society (Smith, Cokkinides, & Eyre, 2005). Stool-based deoxyribonucleic acid (DNA) testing for CRC is considered a promising technology (Smith, Cokkinides, & Eyre, 2003). Numerous features of three noninvasive stool tests for CRC are...
متن کاملMultitarget Stool DNA Testing for Colorectal-Cancer Screening
From the Department of Medicine, Indiana University School of Medicine, the Regenstrief Institute, the Simon Cancer Center, and the Center for Innovation at Roudebush Veterans Affairs Medical Center — all in Indianapolis (T.F.I.); the Departments of Medicine and Epidemiology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill (D.F.R.); the Dr...
متن کاملMultitarget stool DNA testing for colorectal-cancer screening.
BACKGROUND An accurate, noninvasive test could improve the effectiveness of colorectal-cancer screening. METHODS We compared a noninvasive, multitarget stool DNA test with a fecal immunochemical test (FIT) in persons at average risk for colorectal cancer. The DNA test includes quantitative molecular assays for KRAS mutations, aberrant NDRG4 and BMP3 methylation, and β-actin, plus a hemoglobin...
متن کاملMolecular screening testing for colorectal cancer.
Worldwide, colorectal cancer is diagnosed in f1 million individuals each year, accounting for >9% of all new cancer cases (1). Approximately 529,000 people worldwide die of this disease annually. In 2006, it is estimated that 146,000 cases of colorectal cancer will occur in the United States with 55,000 deaths (2). Colorectal cancer is an excellent candidate for population-based screening becau...
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ژورنال
عنوان ژورنال: BMJ
سال: 2000
ISSN: 0959-8138
DOI: 10.1136/bmj.321.7256.254